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Morphological Development of Thick-Tufted Layer V Pyramidal Cells in the Rat Somatosensory Cortex

机译：大鼠体感皮层中厚簇簇V锥体细胞的形态学发育

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The thick-tufted layer V pyramidal (TTL5) neuron is a key neuron providing output from the neocortex. Although it has been extensively studied, principles governing its dendritic and axonal arborization during development are still not fully quantified. Using 3-D model neurons reconstructed from biocytin-labeled cells in the rat somatosensory cortex, this study provides a detailed morphological analysis of TTL5 cells at postnatal day (P) 7, 14, 21, 36, and 60. Three developmental periods were revealed, which were characterized by distinct growing rates and properties of alterations in different compartments. From P7 to P14, almost all compartments grew fast, and filopodia-like segments along apical dendrite disappeared; From P14 to P21, the growth was localized on specified segments of each compartment, and the densities of spines and boutons were significantly increased; From P21 to P60, the number of basal dendritic segments was significantly increased at specified branch orders, and some basal and oblique dendritic segments were lengthened or thickened. Development changes were therefore seen in two modes: the fast overall growth during the first period and the slow localized growth (thickening mainly on intermediates or lengthening mainly on terminals) at the subsequent stages. The lengthening may be accompanied by the retraction on different segments. These results reveal a differential regulation in the arborization of neuronal compartments during development, supporting the notion of functional compartmental development. This quantification provides new insight into the potential value of the TTL5 morphology for information processing, and for other purposes as well.
机译：厚簇状V锥体（TTL5）神经元是提供新皮质输出的关键神经元。尽管已经对其进行了广泛的研究，但在开发过程中控制其树突状和轴突乔化的原理仍未完全量化。使用从大鼠体感皮层中生物素标记的细胞重建的3-D模型神经元，该研究提供了出生后第7、14、21、36和60天TTL5细胞的详细形态分析。揭示了三个发育时期，其特征在于不同隔室中不同的增长率和变化特性。从P7到P14，几乎所有隔室都快速生长，沿着根尖的树突状丝状伪足消失了。从P14到P21，生长局限于每个隔室的指定节段，并且刺和钮扣的密度显着增加。从P21到P60，在指定的分支顺序下，基础树突节的数量显着增加，并且一些基础和倾斜的树突节被延长或增厚。因此，发展变化有两种模式：第一阶段的总体快速增长和随后阶段的局部增长缓慢（主要是中间产品的增厚或主要是终端的加长）。延长可能伴随着不同段的缩回。这些结果揭示了在发育期间神经元区室的树突化过程中的差异调节，支持了功能性区室发育的概念。这种量化为信息处理和其他目的提供了TTL5形态潜在价值的新见解。

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